Experience life as an ant: fight for queen and colony, face hungry spiders and menacing hordes of enemy ants, eat yummy caterpillars, and drive those yucky humans out of the house! Based on real ants, SimAnt has the depth of play and serious gaming challenge to really drive you buggy. SimAnt is about the closest you'll get to being an ant without growing more legs, removing your brain and living in a hole in the ground.

SimCity (SNES) was the first console game in the SimCity series, and one of the launch titles for the Super Famicom/Super Nintendo Entertainment System in North America. It was developed by Nintendo EAD under license from Maxis and published by Nintendo in 1991.

SimCity 2000 (SC2K) is a city-building simulation video game and the second installment in the SimCity series. SimCity 2000 was first released by Maxis in 1994 for computers running Apple Macintosh Operating System. It was later released on the Amiga, DOS & Microsoft Windows, followed by a release for OS/2. In 1995, SimCity 2000 won "Best Military or Strategy Computer Game" Origins Award.

SimTown is a 1995 video game published by Maxis, much like the best selling SimCity but on a smaller scale. SimTown allows the player to construct a town consisting of streets, houses, businesses and parks and then control the people in it. SimTown was one of the many 'Sim' spin-offs at the time, and was targeted more towards children.The Super Famicom/Super Nintendo Entertainment System version of SimTown is called SimCity Jr. (シムシティJr.?). It was published by Imagineer.

SimEarth: The Living Planet is the second life simulation video game designed by Will Wright, in which the player controls the development of a planet. The game was published in 1990 by Maxis. Versions were made for the Apple Macintosh, Commodore Amiga, IBM PC, SNES, Sega Mega-CD and TurboGrafx-16. It was also subsequently re-released on the Wii Virtual Console.

Sink or Swim is a video game that was released in 1993 for the PC under the DOS environment. Developed by Zeppelin Games Limited, it was an action/puzzle game very similar in style to Lemmings. Versions also made their way onto the Amiga and the SNES. The Sega Mega Drive/Genesis and Game Gear versions are known as S.S. Lucifer: Man Overboard!. The game was the first demo disk attached to PC Gamer magazine.

Sküljagger: Revolt of the Westicans is a 2D action platformer video game that was released exclusively for the North American Super Nintendo Entertainment System in 1992.

Slayers (スレイヤーズ, Sureiyāzu?) is a Japanese comic fantasy media franchise originating in a series of over 52 light novels written by Hajime Kanzaka and illustrated by Rui Araizumi. The novels had been serialized in Dragon Magazine, and were later adapted into several manga titles, televised anime series, anime films, OVA series, role-playing video games, and other media. Slayers follows the adventures of teenage sorceress Lina Inverse and her companions as they journey through their world. Using powerful magic and swordsmanship they battle overreaching wizards, demons seeking to destroy the world, and an occasional hapless gang of bandits. The anime series is considered to be one of the most popular of the 1990s.

Smart Ball is an Action-adventure game for the Super Nintendo Entertainment System, known as Jelly Boy (ジェリーボーイ?) in Japan. A sequel called Jelly Boy 2 (ジェリーボーイ2?) was in production, but was never actually released.

Smash TV, known as Super Smash TV on some other versions, is a 1990 arcade game created by Eugene Jarvis and Mark Turmell for Williams. It is a run and gun game in the same vein as its predecessor, Robotron: 2084 (also produced by Jarvis). As in the previous game, players battle waves of enemies by using guns; the arcade version even uses the two-joystick control system of Robotron. The plot of Smash TV revolves around a futuristic game show in which players compete for various prizes, as well as their lives. Home versions were developed for various platforms, most of which were published by Acclaim Entertainment.

Snoopy Concert (スヌーピーコンサート?) is a Japan-exclusive action video game based on the Snoopy cartoon characters licensed from Peanuts and United Feature Syndicate (now a part of United Media), which was released for the Super Famicom in 1995.

Soccer Kid is a platform video game created by UK-based developer Krisalis and released in 1993 for the Commodore Amiga, Super NES, and 3DO Interactive Multiplayer.[citation needed] Its title for the Super NES in the United States is The Adventures of Kid Kleets. It was re-released for the Game Boy Advance on September 30, 2002 and the PlayStation on December 13, 2003. The goal of the game is to guide a little soccer player boy through various levels, using his soccer ball as the main tool. The player character can perform runs, shots, bicycle kicks, headers and other sorts of soccer moves to either advance in the level or eliminate enemies.